- Classifier list
- Reference groups (Classifier 12.2)
- SARC (RMS-like)
- Name: Methylation class sarcoma (RMS-like)
- Description: The methylation class "sarcoma (RMS-like)" is based on tumours with the histological diagnosis of malignant CNS sarcoma / tumour not otherwise specified. Median age is 7 years (age range 0 to 76). The molecular hallmark of this class are DICER1 mutations (>90%), either somatic or inherited, often together with MAPK pathway alterations (>70%). Copy number profiles range from relatively flat to complex. Rhabdomyosarcoma of the genitourinary tract with DICER1 mutations may also assign to this methylation class. The name given here is provisional.
- Histological diagnosis:
||Age [median (min-max)]
||NA (NA - NA)