- Classifier list
- Reference groups (Classifier 12.2)
- SARC (MPNST-like)
- Name: Methylation class sarcoma (MPNST-like)
- Description: The methylation class "sarcoma (MPNST-like)" is based on tumours with typical morphological features of malignant peripheral nerve sheath tumour, but retained expression of the H3K27 trimethylation marker. These tumours often are located (para-)spinal; median age is 50 years (age range 10 to 77). Copy number alterations are numerous with frequent losses on chromosome arm 3q (>80%), 5q (>80%), 9p (100%) and 17q (>70%). Copy number analysis shows a high frequency of CDKN2A/B homozygeous deletions on chromosome arm 9p (> 40%). Further molecular features of this class include mutations in NF1. The name given here is provisional.
- Histological diagnosis:
||Age [median (min-max)]
||NA (NA - NA)