- Classifier list
- Reference groups (Classifier 12.2)
- Name: Methylation class malignant rhabdoid tumour
- Description: The methylation class "malignant rhabdoid tumour" is based on tumours with the histological diagnosis of malignant rhabdoid tumour. Cases of this class comprise tumours located in the renal and extrarenal region (without the CNS); median age is 1 year (age range 0 to 11). Copy number analysis shows a frequent segmental deletion on chromosome arm 22q11.2 involving the SMARCB1 locus (>80%). Almost all cases of this methylation class present with loss of nuclear INI-1 expression.
- Histological diagnosis:
||Age [median (min-max)]
||NA (NA - NA)