- Classifier list
- Reference groups (Classifier 12.2)
- Name: Methylation class malignant peripheral nerve sheath tumour
- Description: The methylation class "malignant peripheral nerve sheath tumour" is based on tumours with the histological diagnosis of malignant peripheral nerve sheath tumour, either sporadic or associated with Von Recklinghausen's Disease (neurofibromatosis type 1). Cases of this class are mostly located in the retroperitoneum and the extremities; median age is 22 years (age range 9 to 54). Copy number alterations are numerous with frequent gains involving chromosome arm 7p (60%), 8q (70%), segmental gains of 17q (60%), and losses on chromosome arm 1p (60%), 9p (>60%), 10q (>60%), 11q (>70%) and a distinct segmental deletion of 17q11.2 (>60%) covering the NF1 locus. All cases of this class have a loss of histone H3K27 trimethylation.
- Histological diagnosis:
||Age [median (min-max)]
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