- Classifier list
- Reference groups (Classifier 12.2)
- CHORD (DD)
- Name: Methylation class chordoma (dedifferentiated)
- Description: The methylation class "chordoma (dedifferentiated)" is based on tumours with the histological diagnosis of poorly differentiated chordoma. Location is mostly the skull base; median age is 7 years (age range 1 to 17). Copy number analysis shows a recurrent deletion of the SMARCB1 locus on chromosome arm 22q (>50%). Otherwise, the copy number profile is flat. All cases of this methylation class lack INI-1 expression.
- Histological diagnosis:
||Age [median (min-max)]
||NA (NA - NA)