- Classifier list
- Reference groups (Classifier 2.4)
- Name: Methylation class meningeom benign-2
- Description: Meningiomas of methylation class benign-2 have usually flat copy-number-profiles and are enriched for cases with TRAF7 mutations in combination with mutations of AKT1 or KLF4, and for SMO mutations. Cases with meningothelial (particularly enriched for AKT1/TRAF7 mutations) or secretory (KLF4 mutation) histology mostly fall into this methylation class. Risk of recurrence after complete resection is low. If present, AKT1E17K mutations offer a target for treatment in cases in which complete resection is not feasible.
- Histological diagnosis:
||Age [median (min-max)]
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