- Classifier list
- Reference groups (Classifier 8.0)
- SARC (DICER1)
- Name: Methylation class (myo-)sarcoma with DICER1 mutation
- Description: The methylation class "(myo-)sarcoma with DICER1 mutation" is based on tumors with the histological diagnosis of malignant tumors not otherwise specified. Median age is 9 years (age range 6 to 76). Molecularly, all cases of this class carry a DICER1 mutation, either somatic or inherited, often together with MAPK pathway alterations. MyoD expression is frequently observed in younger patients. Patients of higher age frequently lack unambiguous myomarker expression. Copy number profiles can range from relatively flat to complex. The name given here is provisional.
- Histological diagnosis:
||Age [median (min-max)]
||NA (NA - NA)