1. Classifier list
2. Reference groups (Classifier 11b4)
3. GBM, G34

Methylation class glioblastoma, IDH wildtype, H3.3 G34 mutant

• Name: Methylation class glioblastoma, IDH wildtype, H3.3 G34 mutant
  
  
• Description: The methylation class "glioblastoma, IDH wildtype, H3.3 G34 mutant" almost exclusively comprises tumors with glioblastoma, IDH wildtype histology as well as rare cases with anaplastic astrocytoma, IDH wildtype or embryonal histology. Location is typically in the supratentorial hemispheres; Median age is 19.5 years (range 0 to 40). The vast majority of cases in this class harbor mutations of codon 34 of the H3.3 gene (H3F3A). Copy number changes are numerous, with gain of 1q and 7 (>40% of cases) and (focal) loss of 4q, 10q and 13 (each in over 40%) being most frequent
  
  
• Histological diagnosis: Glioblastoma, IDH-wildtype (40; 97.6%); Anaplastic astrocytoma, IDH-wildtype (1; 2.4%)
  
  
• Localisation: supra (17; 100%)