1. Classifier list
2. Reference groups (Classifier 11b4)
3. ANA PA

Methylation class anaplastic pilocytic astrocytoma

• Name: Methylation class anaplastic pilocytic astrocytoma
  
  
• Description: The methylation class "anaplastic pilocytic astrocytoma" is mainly comprised of tumors with the histological diagnosis of anaplastic pilocytic astrocytoma or less commonly glioblastoma. The tumors mostly occur in the posterior fossa and rarely in the diencephalic/thalamic region; median age is 40 years (age range 24 to 75). Deletions of CDKN2A/B are very frequent (>70%). BRAF duplications are also observed in a fraction of cases. Around 50% of cases show an immunohistochemical loss of ATRX. Loss of chromosome 19q (total or partial) is observed in over 50% of cases.
  
  
• Histological diagnosis: Anaplastic pilocytic astrocytoma (unresolved status) (14; 66.7%); Glioblastoma, IDH-wildtype (5; 23.8%)
  
  
• Localisation: PF (18; 85.7%), supra (3; 14.3%), spinal (1; 4.8%)