MNP - Reference class details

Name: Methylation class CNS high grade neuroepithelial tumor with BCOR alteration
Description: The methylation class "CNS high grade neuroepithelial tumor with BCOR alteration" is mainly comprised of tumors with the histological diagnosis CNS embryonal tumor, NOS; anaplastic ependymoma and glioblastoma, IDH wildtype. Tumors can be located supratentorially or in the posterior fossa. The age at diagnosis is typically under 18 years with rare exceptions; median age is 5 years (range 1 to 26). Molecularly, most cases harbor an internal tandem duplication in the BCOR gene. Rare cases harbor BCOR mutations. Up to 20% of cases show a gain of chromosome 1q, otherwise no recurrent copy number changes are observed and most cases show a flat profile in copy number analysis.
Histological diagnosis: CNS embryonal tumour, NOS (12; 54.5%); Anaplastic ependymoma (4; 18.2%)
Localisation: supra (12; 75%), PF (4; 25%)

Sample count	Ratio male/female	Age [median (min-max)]
23	0.92	5.0 (1.0 - 26.0)

Methylation class CNS high grade neuroepithelial tumor with BCOR alteration