- Classifier list
- Reference groups (Classifier 11b4)
- Name: Methylation class embryonal tumor with multilayered rosettes
- Description: The methylation class "embryonal tumor with multilayered rosettes" is comprised of tumors with the diagnosis embryonal tumor with multilayered rosettes, C19MC-altered. The majority of tumors are located supratentorially. Median age is 3 years (range 2 to 3). Molecularly, these aggressive tumors frequently harbor amplification of the C19MC miRNA cluster (all cases of reference cohort) together with a TTYH1-C19MC fusion. Gain of one copy of chromosome 2 is frequently also observed (>60% of cases), and expression of LIN28A is high at both mRNA and protein level. Rarely, tumors with this molecular phenotype but lacking the C19MC amplification may be seen.
- Histological diagnosis: Embryonal tumour with multilayered rosettes, C19MC-altered (43; 100%); NA
- Localisation: NA
||Age [median (min-max)]
||3.0 (2.0 - 3.0)